School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310012, P R China.
Dalton Trans. 2012 Jun 7;41(21):6371-89. doi: 10.1039/c2dt12159j. Epub 2012 Mar 6.
Iron is essential for the proper functioning of all living cells, however it is toxic when present in excess. Thus, using iron chelators as therapeutic agents, namely chelation therapy, has received increasing attention. The objective of this review is to discuss the factors which should be considered when designing clinically useful iron chelators, to present the application of iron chelators in the treatment of iron overload associated with β-thalassaemia major and sickle cell anaemia, and to highlight the potential applications in the treatment of neurodegenerative disorders and microbial infection. This article reviews recent knowledge centred on these themes and indicates the growing importance of the concept of iron chelation in medicine.
铁是所有活细胞正常运作所必需的，但过量存在时会有毒性。因此，使用铁螯合剂作为治疗剂，即螯合疗法，受到了越来越多的关注。本综述的目的是讨论在设计临床上有用的铁螯合剂时应考虑的因素，介绍铁螯合剂在治疗与重型β-地中海贫血和镰状细胞贫血相关的铁过载方面的应用，并强调其在治疗神经退行性疾病和微生物感染方面的潜在应用。本文综述了这些主题的最新知识，并指出了铁螯合概念在医学中的重要性日益增加。
