Zapantis Antonia, Steinberg Jennifer G, Schilit Lea
Pharmacy Practice Department, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
J Pharm Pract. 2012 Apr;25(2):222-31. doi: 10.1177/0897190011431636.
With a substantial number of women using herbal products to augment their milk production, this article will review available literature illustrating efficacy and adverse effects of using these products. Embase, PubMed, and EBSCO (all databases) were searched from inception to June 2011 using terms such as ‘‘galactagogue,’’ ‘‘galactogogue,’’ ‘‘herbal,’’ and ‘‘botanical’’ and the search was subsequently narrowed to specific herbals by name. Additional articles were obtained from article reference lists. Supplemental information was obtained with Natural Standard. All abstracts retrieved were evaluated for relevance and germane articles were included. Numerous lactation-stimulating herbals have been identified in the literature with varying degrees of evidence,mostly anecdotal. Use of torbangun, milk thistle, and fenugreek may correlate with increased milk supply. Evidence regarding adverse effects, pharmacodynamic properties, and pharmacokinetic effects remains scarce. Despite the fact that postpartum women may turn to herbal galactagogues, scant clinical evidence exists to justify their effectiveness. Further clinical trials are needed in order to substantiate these findings.
鉴于大量女性使用草药产品来增加乳汁分泌,本文将回顾现有文献,阐述这些产品的功效及不良反应。从数据库建立至2011年6月,我们使用了“催乳剂”“催奶剂”“草药”和“植物药”等术语在Embase、PubMed和EBSCO(所有数据库)中进行检索,随后按名称将检索范围缩小至特定草药。通过文章参考文献列表获取了其他文章。利用自然标准(Natural Standard)获取了补充信息。对检索到的所有摘要进行相关性评估,并纳入相关文章。文献中已确定了多种具有不同程度证据(大多为轶事证据)的催乳草药。使用刺蒴麻、水飞蓟和胡芦巴可能与乳汁分泌增加有关。关于不良反应、药效学特性和药代动力学效应的证据仍然很少。尽管产后女性可能会求助于草药催乳剂,但几乎没有临床证据能证明其有效性。需要进一步的临床试验来证实这些发现。