Li Yujie, Yang Qing, Weng Xiaogang, Chen Ying, Li Dan, Zou Lijuan, Zhu Xiaoxin
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2011 Dec;36(23):3353-7.
To investigate the effects of Tiangou Jiangya capsule on blood pressure of spontaneous hypertensive rats.
The 13-14 week SPF rats were selected and randomly divided into model groups, the low, middle, high dose of Tiangou Jiangya capsule groups, positive control group administrated with captopril. Drugs were intragastric administrated once per day, lasting four weeks. The blood pressure, heart rate, heart ventricle indexes, urinary volume and the level of PRA,angiotensing II (Ang II), aldosterone (ALD) of rats were observed.
The low, middle, high dose of Tiangou Jiangya capsule can remarkably reduce the systolic pressure, diastolic pressure and mean arterial pressure of spontaneous hypertensive rats (P < 0.05 or P < 0.01). The low, middle dose can reduce the heart rate of rats (P < 0.01). The low dose can effectively inhibit the left ventricle indexes (P < 0.05). The Tiangou Jiangya capsule has no markedly effects on the renin-angiotensin-aldosterone system (RAAS) activity and urinary output of rats.
The results indicate that the Tiangou Jiangya capsule has evident effect of lowering blood pressure of rats, which is related to reducing heart rate, heart ventricle indexes, and has no effect on the RAAS and diuresis.
探讨天钩降压胶囊对自发性高血压大鼠血压的影响。
选取13 - 14周龄的SPF大鼠，随机分为模型组、天钩降压胶囊低、中、高剂量组、卡托普利阳性对照组。每天灌胃给药1次，持续4周。观察大鼠的血压、心率、心室指数、尿量以及血浆肾素活性（PRA）、血管紧张素Ⅱ（AngⅡ）、醛固酮（ALD）水平。
天钩降压胶囊低、中、高剂量组均可显著降低自发性高血压大鼠的收缩压、舒张压及平均动脉压（P < 0.05或P < 0.01）。低、中剂量组可降低大鼠心率（P < 0.01）。低剂量组可有效抑制左心室指数（P < 0.05）。天钩降压胶囊对大鼠肾素 - 血管紧张素 - 醛固酮系统（RAAS）活性及尿量无明显影响。
结果表明天钩降压胶囊具有明显的降血压作用，其作用与降低心率、心室指数有关，对RAAS及利尿无影响。
