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[中药及中成药致肝损伤的研究进展]

[Research progress of Chinese herbal medicine and traditional Chinese medicine resulting in liver injury].

作者信息

Wang Jingli, Zhou Chaofan

机构信息

Pharmacy of Beijisi Retired Cadre Service Administration Clinic, PLA General Staff Administration and Guarantee Ministry, Beijing 100191, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2011 Dec;36(23):3371-4.

Abstract

The adverse reactions caused by Chinese herbal medicine and traditional Chinese medicine are reported increased in recent years, among which the acute liver injury caused by Chinese herbal medicine accounts for 21.5% of total liver injuries. Despite the misuse of traditional Chinese medicine not in accordance with differentiation of symptoms and signs, the adverse reaction of Chinese herbal medicine itself can't be little to these adverse events. The paper summarizes the most common categories of traditional Chinese medicine resulting in liver injury, the mechanism, pathological characteristics, clinical symptom of liver injury, the reasons of the reaction and how to prevent. The research aims to enhance the clinical physician recognition of liver injury caused by Chinese herbal medicine, in order to ensure the safe and rational usage of traditional Chinese medicine.

摘要

近年来,关于中草药和中药引起的不良反应报道有所增加,其中中草药所致急性肝损伤占全部肝损伤的21.5%。尽管存在不遵循辨证论治滥用中药的情况,但中草药自身的不良反应对这些不良事件也难辞其咎。本文总结了导致肝损伤的最常见中药类别、机制、病理特征、肝损伤的临床症状、反应原因以及如何预防。该研究旨在提高临床医生对中草药所致肝损伤的认识,以确保中药的安全合理使用。

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