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博洛尼亚西部社区心理健康中心的首发精神病:一项8年前瞻性研究的结果。

First-episode psychosis at the West Bologna Community Mental Health Centre: results of an 8-year prospective study.

作者信息

Tarricone I, Mimmi S, Paparelli A, Rossi E, Mori E, Panigada S, Carchia G, Bandieri V, Michetti R, Minenna G, Boydell J, Morgan C, Berardi D

机构信息

Institute of Psychiatry, Bologna University, Italy.

Public Health Department, Bologna University, Italy.

出版信息

Psychol Med. 2012 Nov;42(11):2255-64. doi: 10.1017/S0033291712000335. Epub 2012 Mar 7.

Abstract

BACKGROUND

Research mostly conducted in the UK and northern Europe has established that there are high rates of first-episode psychosis (FEP) in large cities and immigrant populations; moreover, psychosis has been found to be associated with cannabis use and early trauma. The present study aimed to evaluate the incidence rate of FEP and the distribution of several risk factors (e.g. age, ethnicity, substance abuse) in Bologna, Italy.

METHOD

The Bologna FEP (BoFEP) study is an 8-year prospective study. All FEP patients, 18-64 years old, consecutively referred to the West Bologna Community Mental Health Centre (CMHC) from 2002 to 2009 were evaluated. Sociodemographic information, migration history and clinical data were collected through an ad-hoc schedule. Psychiatric diagnoses were recorded using the Schedule for Clinical Assessment of Neuropsychiatry (SCAN).

RESULTS

The overall incidence rate (IR) in the BoFEP study was 16.4 per 100 000 person-years [95% confidence interval (CI) 13.9-18.9]. The incidence was higher in young people, men and migrants (MI).

CONCLUSIONS

The IR of FEP found by the Bologna study is lower than that found by other European studies. However, as in other studies, the incidence was higher in certain groups. This heterogeneity has implications for policy and mental health service development, and for understanding the aetiology of psychosis.

摘要

背景

大多在英国和北欧开展的研究证实,大城市和移民群体中首发精神病(FEP)的发病率很高;此外,已发现精神病与大麻使用及早期创伤有关。本研究旨在评估意大利博洛尼亚FEP的发病率以及若干风险因素(如年龄、种族、药物滥用)的分布情况。

方法

博洛尼亚FEP(BoFEP)研究是一项为期8年的前瞻性研究。对2002年至2009年期间连续转诊至博洛尼亚西部社区精神卫生中心(CMHC)的所有18 - 64岁的FEP患者进行了评估。通过一份专门的调查表收集社会人口学信息、移民史和临床数据。使用神经精神病学临床评估量表(SCAN)记录精神科诊断。

结果

BoFEP研究中的总体发病率(IR)为每10万人年16.4例[95%置信区间(CI)13.9 - 18.9]。年轻人、男性和移民(MI)的发病率较高。

结论

博洛尼亚研究发现的FEP发病率低于其他欧洲研究。然而,与其他研究一样,某些群体的发病率较高。这种异质性对政策制定和精神卫生服务发展以及对理解精神病的病因学具有重要意义。

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