Calabria Ferdinando, Chiaravalloti Agostino, Di Pietro Barbara, Grasso Cristina, Schillaci Orazio
Department of Nuclear Medicine and Molecular Imaging, IRCCS Neuromed, Pozzilli (IS), Italy.
Nucl Med Commun. 2012 Jun;33(6):563-70. doi: 10.1097/MNM.0b013e328351d566.
The objective of this study was to give an overview of the potential clinical utility of [18F]-L-dihydroxyphenylalanine (18F-DOPA) PET and PET/CT for imaging of brain tumors. Review articles and reference lists were used to supplement the search findings. 18F-DOPA has been investigated as a PET tracer for primary brain tumors, metastases of somatic cancer, and evaluation of relapse of pathology in patients with brain tumor after surgery and/or radiotherapy on the basis of enhanced cell proliferation. Available studies have provided encouraging preliminary results for diagnosis of brain tumors and relapse after surgery/radiotherapy. In the brain, excellent discrimination between tumor and normal tissue can be achieved because of the low physiological uptake of 18F-DOPA and the high ratio between tumor and normal hemispheric tissue. Information on evaluation of brain metastases is limited but encouraging. PET and PET/CT with 18F-DOPA are useful in diagnosing primary brain tumors and should be recommended in the diagnosis of relapse of disease after surgical treatment and/or radiotherapy. Semiquantitative analysis could improve diagnosis while correlative imaging with MRI is essential. Limits are due to low knowledge of potential pitfalls.
本研究的目的是概述[18F]-L-二羟基苯丙氨酸（18F-DOPA）PET和PET/CT在脑肿瘤成像方面的潜在临床应用价值。通过综述文章和参考文献列表来补充检索结果。18F-DOPA已作为一种PET示踪剂，用于基于细胞增殖增强对原发性脑肿瘤、体癌转移以及脑肿瘤患者术后和/或放疗后病理复发的评估。现有研究为脑肿瘤的诊断以及手术/放疗后的复发提供了令人鼓舞的初步结果。在脑部，由于18F-DOPA的生理性摄取较低，且肿瘤与正常半球组织之间的比例较高，因此可以实现肿瘤与正常组织之间的良好区分。关于脑转移瘤评估的信息有限，但令人鼓舞。18F-DOPA PET和PET/CT在原发性脑肿瘤的诊断中很有用，并且在手术治疗和/或放疗后疾病复发的诊断中应予以推荐。半定量分析可以改善诊断，而与MRI的相关成像至关重要。局限性在于对潜在陷阱的了解不足。
