Alizadeh Farshid, Khorrami Mohammad Hatef, Izadpanahi Mohammad Hossein, Nouri-Mahdavi Kia, Mohammadi Sichani Mehrdad
Isfahan Urology and Renal Transplantation Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Urol J. 2012 Winter;9(1):347-50.
To review different aspects of the bladder involvement in Behcet's disease as a rare complication.
We searched PubMed, Ovid, and Google Scholar for Behcet's and neuro-Behcet's disease and neurogenic and neuropathic bladder, bladder involvement, voiding dysfunction, and urologic manifestations. Fourteen full-texts and one abstract were retrieved.
Most involved patients are young to middle-aged men. Both bladder filling and emptying problems can be seen, with the storage symptoms being the most common finding. Sphincter function could be normal, dyssynergic, or deficient. The most common urodynamic finding is detrusor overactivity. In cystoscopic examination, ulcers or nodules due to vasculitis can be seen, which along with neurologic causes give rise to the voiding symptoms. The rate of cancers does not increase in Behcet's disease. Surgery and chemotherapy are tolerated well. However, radiotherapy may be associated with increased complication rates.
Treatment plan should be tailored according to the specific type of the bladder involvement. Periodic re-evaluation is required because of the changing nature of the bladder behavior.
回顾白塞病累及膀胱这一罕见并发症的不同方面。
我们在PubMed、Ovid和谷歌学术上搜索白塞病、神经白塞病以及神经源性和神经性膀胱、膀胱受累、排尿功能障碍及泌尿系统表现。检索到14篇全文和1篇摘要。
大多数受累患者为中青年男性。膀胱充盈和排空问题均可见，储尿症状是最常见的表现。括约肌功能可能正常、协同失调或功能不全。最常见的尿动力学表现是逼尿肌过度活动。膀胱镜检查可见血管炎所致的溃疡或结节，这些与神经因素共同导致排尿症状。白塞病患者的癌症发生率并未增加。手术和化疗耐受性良好。然而，放疗可能会使并发症发生率增加。
治疗方案应根据膀胱受累的具体类型进行调整。由于膀胱情况不断变化，需要定期重新评估。
