Kitamura Y, Watanabe M, Komatsubara S, Sakata Y
Department of Urology, Niigata Cancer Center Hospital.
Hinyokika Kiyo. 1990 Sep;36(9):991-6.
The plasma methotrexate (MTX) concentration was measured during 50 courses of chemotherapy on 26 urothelial cancer patients. A dose of 300 mg/body MTX was infused within 2 hours and plasma concentrations were measured at the scheduled times. Plasma level at the end of infusion was (2.3 +/- 0.8) x 10(-5) M/L, (2.9 +/- 1.9) x 10(-5) M/L at the 6th-hour, and (1.9 +/- 1.8) x 10(-7) M/L at the 24th-hour after the infusion. The plasma MTX concentration values were inversely correlated with creatinin clearance. In 6 cases of Kock pouch bladder, clean intermittent self catheterization of urine caused no meaningful increase of MTX.
在对26例尿路上皮癌患者进行的50个化疗疗程中，测定了血浆甲氨蝶呤（MTX）浓度。在2小时内静脉输注300mg/体的MTX，并在预定时间测量血浆浓度。输注结束时的血浆水平为(2.3±0.8)×10⁻⁵M/L，输注后第6小时为(2.9±1.9)×10⁻⁵M/L，第24小时为(1.9±1.8)×10⁻⁷M/L。血浆MTX浓度值与肌酐清除率呈负相关。在6例Kock贮尿囊膀胱患者中，清洁间歇性自我导尿未导致MTX有意义的增加。
