成人睾丸旁横纹肌肉瘤（PRMS）患者的临床病理特征及治疗结果：一项为期10年的单中心经验
Clinicopathological characteristics and treatment outcomes of adult patients with paratesticular rhabdomyosarcoma (PRMS): A 10-year single-centre experience.
作者信息
Keskin Serkan, Ekenel Meltem, Basaran Mert, Kilicaslan Isin, Tunc Murat, Bavbek Sevil
机构信息
Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey;
出版信息
Can Urol Assoc J. 2012 Feb;6(1):42-5. doi: 10.5489/cuaj.11121.
INTRODUCTION
We report our experience with 8 consecutive adults treated for paratesticular rhabdomyosarcoma (RMS) at a single institution between 2000 and 2010.
METHODS
After primary surgical excision, 7 patients were classified into group I according to the Intergroup Rhabdomyosarcoma Study Group (IRSG) Postsurgical Grouping Classification, and 1 patient into group IIB. Retroperitoneal node dissection was not a required staging procedure. Adjuvant chemotherapy was administered to 7 of the 8 patients. No additional radiotherapy was administered.
RESULTS
The median age at diagnosis was 24 years (range: 18-60). Embryonal histology was the most common (75%) subtype. During follow-up, 3 patients experienced local relapse and 5 distant relapse. The median progression-free and overall survival times were 17.0 ± 9.9 months (range: 5-31) and 27.3 ± 1.3 months (range: 16-58), respectively.
CONCLUSION
Paratesticular RMS is an uncommon malignancy in adults. We confirm that patients with localized paratesticular RMS may have different prognoses. Retroperitoneal lymphadenectomy can be avoided as a treatment for paratesticular RMS after radical inguinal orchiectomy.
引言
我们报告了2000年至2010年间在单一机构对8例连续性成年睾丸旁横纹肌肉瘤（RMS）患者的治疗经验。
方法
在进行初次手术切除后，根据横纹肌肉瘤协作组（IRSG）术后分组分类，7例患者被归入I组，1例患者被归入IIB组。腹膜后淋巴结清扫术并非必需的分期程序。8例患者中有7例接受了辅助化疗。未进行额外的放疗。
结果
诊断时的中位年龄为24岁（范围：18 - 60岁）。胚胎型组织学是最常见的（75%）亚型。在随访期间，3例患者出现局部复发，5例出现远处复发。无进展生存期和总生存期的中位时间分别为17.0±9.9个月（范围：5 - 31个月）和27.3±1.3个月（范围：16 - 58个月）。
结论
睾丸旁RMS在成年人中是一种罕见的恶性肿瘤。我们证实，局限性睾丸旁RMS患者可能有不同的预后。根治性腹股沟睾丸切除术后，可避免将腹膜后淋巴结清扫术作为睾丸旁RMS的一种治疗方法。
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