心肌梗死患者中铟-111抗肌球蛋白单克隆抗体的持续摄取。
Persistent uptake of indium-111-antimyosin monoclonal antibody in patients with myocardial infarction.
作者信息
Matsumori A, Yamada T, Tamaki N, Kawai C, Watanabe Y, Yonekura Y, Endo K, Konishi J, Yoshida A, Tamaki S
机构信息
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
出版信息
Am Heart J. 1990 Nov;120(5):1026-30. doi: 10.1016/0002-8703(90)90113-c.
Indium-111(111In)-antimyosin scintigraphy was investigated in 27 patients with myocardial infarction. 111In-antimyosin Fab was administered intravenously, and planar and single photon emission computed tomographic images were obtained 48 hours later. Uptake of 111In-antimyosin was present in 9 of 10 patients (90%) studied within 6 days of infarction. During the second week positive scans were seen in 16 of 16 patients (100%) including 13 (81%) who had normal creatine kinase levels. The mechanism of persistent positive antimyosin images in the subacute stage of myocardial infarction remains to be clarified. 111In-antimyosin scintigraphy may be useful as a noninvasive method for the detection of myocardial injury late and early after a suspected acute myocardial infarction.
对27例心肌梗死患者进行了铟-111（¹¹¹In）抗肌凝蛋白闪烁显像研究。静脉注射¹¹¹In抗肌凝蛋白Fab，48小时后获得平面和单光子发射计算机断层图像。在梗死6天内研究的10例患者中有9例（90%）出现¹¹¹In抗肌凝蛋白摄取。在第二周，16例患者（100%）扫描呈阳性，其中13例（81%）肌酸激酶水平正常。心肌梗死亚急性期抗肌凝蛋白图像持续阳性的机制尚待阐明。¹¹¹In抗肌凝蛋白闪烁显像可能作为一种无创方法，用于检测疑似急性心肌梗死后早期和晚期的心肌损伤。
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