Moreyra A E, Macris A, Kostis J B, Scholz P
Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903-0019.
Am Heart J. 1990 Nov;120(5):1031-8. doi: 10.1016/0002-8703(90)90114-d.
The effectiveness of a coronary perfusion catheter was studied in an animal model of acute coronary occlusion. Systemic hemodynamic variables, regional myocardial blood flow (RMBF) in the subepicardium and subendocardium, and regional systolic function (systolic segmental shortening) of the area perfused by the circumflex coronary artery (CX) were measured in eight anesthetized dogs. After baseline measurements, the CX coronary artery was occluded with a silk snare and measurements were repeated after 5 minutes of ischemia (occlusion No. 1). The snare was released and 1 hour later the snare occlusion was repeated after placement of a perfusion catheter in the CX coronary artery. After 5 minutes, measurements were repeated (occlusion No. 2). To determine the long-term effectiveness of the catheter, hemodynamic variables and regional function measurements were then obtained every 15 minutes for a total of 60 minutes. During occlusion No. 1, RMBF decreased from 1.30 +/- 0.20 to 0.41 +/- 0.13 ml.min-1.gm-1 (p less than 0.01), and subendocardial RMBF decreased from 1.44 +/- .24 to 0.34 +/- 0.15 ml.min-1.gm-1 (p less than 0.01). After insertion of the perfusion catheter (occlusion No. 2), subepicardial RMBF was maintained at 0.97 +/- 0.16 and subendocardial RMBF was maintained at 0.78 +/- 0.13 ml.min-1.gm-1; during occlusion No. 2 subepicardial RMBF was greater (p less than 0.05) than occlusion No. 1 and was not different from baseline.(ABSTRACT TRUNCATED AT 250 WORDS)
在急性冠状动脉闭塞的动物模型中研究了冠状动脉灌注导管的有效性。在八只麻醉犬中测量了全身血流动力学变量、心外膜下和心内膜下的局部心肌血流量（RMBF）以及由回旋支冠状动脉（CX）灌注区域的局部收缩功能（收缩节段缩短）。在进行基线测量后，用丝线圈套器阻断CX冠状动脉，并在缺血5分钟后（阻断1号）重复测量。松开圈套器，1小时后在CX冠状动脉中放置灌注导管后再次进行圈套器阻断。5分钟后，重复测量（阻断2号）。为了确定导管的长期有效性，然后每15分钟获取一次血流动力学变量和局部功能测量值，共持续60分钟。在阻断1号期间，RMBF从1.30±0.20降至0.41±0.13 ml·min⁻¹·gm⁻¹（p＜0.01），心内膜下RMBF从1.44±0.24降至0.34±0.15 ml·min⁻¹·gm⁻¹（p＜0.01）。插入灌注导管后（阻断2号），心外膜下RMBF维持在0.97±0.16，心内膜下RMBF维持在0.78±0.13 ml·min⁻¹·gm⁻¹；在阻断2号期间，心外膜下RMBF大于（p＜0.05）阻断1号，且与基线无差异。（摘要截断于250字）
