Dept. of Surgery and Neurosurgery, College of Medicine, Texas A&M Health Science Center, Scott & White Hospital, Central Texas Veterans Health Care System, Temple, TX 76504, USA.
Aging Dis. 2011 Aug;2(4):286-93. Epub 2011 Aug 30.
Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, the number of DCX-labeled cells in the dentate gyrus from aged rats (23 months of age) was assessed 30 days following pilocarpine-induced seizures and was compared to the number obtained from age-matched control rats. DCX-labeled cells were located in the subgranular zone, at the border between the hilus and the granule cell layer, and within the granule cell layer in both epileptic and control aged brains. When comparing the aged epileptic rats to age-matched controls, there was a significant increase in the number of DCX-labeled cells that was almost four and a half-fold. Therefore, aged rats also display an increase in adult neurogenesis following seizures.
海马齿状回中的神经发生在哺乳动物的整个生命周期中都存在，然而，随着动物年龄的增长，神经发生的速度会降低。虽然癫痫发作会增加年轻成年大脑中的神经发生，但这一关系在老年动物中尚未得到证实。通过双皮质素（DCX）免疫细胞化学，评估了匹罗卡品诱导癫痫发作后 30 天来自老年大鼠（23 个月大）齿状回中 DCX 标记细胞的数量，并与来自年龄匹配的对照大鼠获得的数量进行了比较。DCX 标记细胞位于颗粒细胞层和门区之间的颗粒下层，以及在癫痫发作和对照老年大脑中的颗粒细胞层中均有分布。当将老年癫痫发作大鼠与年龄匹配的对照组进行比较时，DCX 标记细胞的数量显著增加，几乎增加了四倍半。因此，癫痫发作后老年大鼠也会增加成年神经发生。
