Ozkal Atay, Sensoy Gülnar, Acuner Cağatay, Belet Nurşen, Güney Akif Koray
Division of Pediatric Infectious Diseases, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
Turk J Pediatr. 2012 Jan-Feb;54(1):15-9.
In this study, we aimed to investigate anti-pertussis immunoglobulin (Ig) G antibodies in the serum of children in our region vaccinated against pertussis with four doses. Between August 2008-2009, antibody levels to Bordetella pertussis (B. pertussis) antigens were studied in 385 serum samples from healthy children aged 1.5-18 years (y) vaccinated against pertussis in Samsun, Turkey. The study population was divided into six groups according to ages: 1.5-3 y; 4-5 y; 6-8 y; 10-12 y; 13-15 y; and 16-18 y. IgG antibodies to B. pertussis antigens were measured with a commercial ELISA kit. Mean age of the children was 9.6 +/- 5.3 y. Anti-pertussis IgG titers were positive in 48.3% of the cases. The lowest positivity rate was determined in the 4-5 y age group (28.1%) and the highest rate in the 16-18 y age group (64.2%). Geometric mean titer of anti-pertussis antibodies was 39.2 IU/ml, and again the lowest value was obtained in the 4-5 y age group (23.3 IU/ml) and the highest in the 16-18 y age group (51.4 IU/ml). The antibody levels to B. pertussis antigens significantly decrease 4-6 years after vaccination and again increase in school children, possibly due to natural infection.
在本研究中，我们旨在调查本地区接种四剂百日咳疫苗的儿童血清中的抗百日咳免疫球蛋白（Ig）G抗体。2008年8月至2009年期间，对土耳其萨姆松385份1.5至18岁接种过百日咳疫苗的健康儿童血清样本进行了针对百日咳博德特氏菌（百日咳杆菌）抗原的抗体水平研究。研究人群根据年龄分为六组：1.5至3岁；4至5岁；6至8岁；10至12岁；13至15岁；以及16至18岁。使用商用ELISA试剂盒测量针对百日咳杆菌抗原的IgG抗体。儿童的平均年龄为9.6±5.3岁。48.3%的病例抗百日咳IgG滴度呈阳性。最低阳性率出现在4至5岁年龄组（28.1%），最高阳性率出现在16至18岁年龄组（64.2%）。抗百日咳抗体的几何平均滴度为39.2 IU/ml，同样最低值出现在4至5岁年龄组（23.3 IU/ml），最高值出现在16至18岁年龄组（51.4 IU/ml）。接种疫苗4至6年后，针对百日咳杆菌抗原的抗体水平显著下降，而学龄儿童中抗体水平再次上升，这可能是由于自然感染所致。
