Coy K M, Imperi G, Lambert C R, Pepine C J
University of Florida, Department of Medicine, Gainesville.
Am J Cardiol. 1990 Nov 6;66(16):22G-24G. doi: 10.1016/0002-9149(90)90389-i.
Circadian variations of transient myocardial ischemia and heart rate have been identified, but the rhythms and their response to beta blockade have not been fully characterized. Time-series analysis, a mathematical technique to describe oscillatory activity occurring within a continuous data set was used, to address these issues. Nine men with coronary artery disease underwent 72 hours of ambulatory electrocardiographic monitoring during therapy with placebo or metoprolol. During administration of placebo, ischemic time and heart rate showed a primary peak with a periodicity of approximately 24 hours with a tight coupling between the 2 variables and a secondary peak with a periodicity of 5 to 8 hours. During metoprolol therapy, heart rate and ischemic variation were reduced and the 24-hour periodicity for heart rate only remained. The 24-hour periodicity for ischemia was eliminated, but the data with 5- to 8-hour periodicity became the major component of the signal.
短暂性心肌缺血和心率的昼夜变化已得到确认，但这些节律及其对β受体阻滞剂的反应尚未完全明确。采用时间序列分析这一用于描述连续数据集中振荡活动的数学技术来解决这些问题。9名冠心病男性患者在接受安慰剂或美托洛尔治疗期间进行了72小时的动态心电图监测。在服用安慰剂期间，缺血时间和心率显示出一个约24小时周期的主要峰值，两个变量之间紧密相关，还有一个5至8小时周期的次要峰值。在美托洛尔治疗期间，心率和缺血变化减少，仅心率的24小时周期仍然存在。缺血的24小时周期被消除，但5至8小时周期的数据成为信号的主要成分。
