Inserm SC14 Centre d'Expertise Collective, Université Paris Diderot Paris, 7 Faculté de Médecine Site Bichat, 16 rue Henri Huchard, 75890, Paris Cedex 18, France.
Expert Rev Anti Infect Ther. 2012 Mar;10(3):341-57. doi: 10.1586/eri.12.10.
Antiparasitic and antifungal drugs have not received the same high level of recognition as antimicrobial drugs. They are comparatively few in number, the great majority of them were developed more than a century ago, they have many adverse side effects and are subject to the emergence of drug resistance. The second part of the review, devoted to the immunomodulatory effects of antimicrobial agents, addresses the interference of antiparasitic and antifungal agents with the host natural defenses and the deleterious or beneficial consequences of these properties.
抗寄生虫和抗真菌药物尚未得到与抗菌药物相同的高度认可。它们的数量相对较少,其中绝大多数是一个多世纪前开发的,它们有许多不良反应,并容易产生耐药性。综述的第二部分专门讨论了抗菌药物的免疫调节作用,涉及抗寄生虫和抗真菌药物对宿主天然防御的干扰以及这些特性的有害或有益后果。