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腹膜后淋巴结清扫术联合 IVC 血栓切除术、腔静脉壁切除术和移植物植入术治疗转移性 NSGCT。

Retroperitoneal lymph node dissection with concomitant IVC thrombectomy, caval wall resection, and grafting for metastatic NSGCT.

机构信息

Department of Urology University of South Florida, Tampa, FL, USA.

出版信息

Int Braz J Urol. 2012 Jan-Feb;38(1):135; discussion 136. doi: 10.1590/s1677-55382012000100020.

DOI:10.1590/s1677-55382012000100020
PMID:22397783
Abstract

INTRODUCTION

The management of a post-chemotherapy retroperitoneal mass secondary to testicular cancer can present a surgical challenge when involving adjacent organs or major vascular structures. We present the first video of a retroperitoneal lymph node dissection (RPLND) with IVC (inferior vena cava) thrombectomy, caval wall resection resulting from metastatic non-seminomatous germ cell testis (NSGCT) cancer.

METHODS

In this surgical video, we highlight important surgical considerations in the management of a postchemotherapy retroperitoneal mass with direct IVC wall invasion and level 2 thrombus in such a patient.

RESULTS

A 34 year old man underwent a right inguinal orchiectomy for a mixed NSGCT (embryonal, yolk sac, and teratoma components) and elevated serum tumor markers. He underwent systemic chemotherapy (BEP regimen x 4 cycles) with subsequent near normalization of tumor markers. His post-chemotherapy imaging revealed a 6 cm residual retroperitoneal mass with a level 2 IVC tumor thrombus and suspected direct infrarenal IVC wall invasion from the mass. The patient underwent an open post-chemotherapy RPLND, IVC thrombectomy, IVC resection and grafting. The final pathology report of the retroperitoneal mass revealed teratoma with no viable germ cell tumor elements and negative surgical margins. His intra-operative and post-operative stages were unremarkable with his IVC graft remaining patent and no evidence of disease recurrence at last follow-up.

CONCLUSION

We present the first surgical video of a post-chemotherapy RPLND with IVC thrombectomy, caval wall resection and grafting for metastatic NSGCT. The final pathology report of teratoma with no viable tumor highlights the local vascular invasive potential of such pathology.

摘要

简介

继发于睾丸癌的化疗后腹膜后肿块的处理在涉及邻近器官或主要血管结构时可能具有挑战性。我们展示了首例伴有 IVC(下腔静脉)血栓切除术、转移性非精原细胞瘤生殖细胞睾丸癌(NSGCT)导致的腔静脉壁切除的腹膜后淋巴结清扫术(RPLND)的视频。

方法

在这个手术视频中,我们强调了处理化疗后腹膜后肿块的重要手术注意事项,该肿块直接侵犯 IVC 壁并伴有 2 级血栓。

结果

一名 34 岁男性因混合 NSGCT(胚胎、卵黄囊和畸胎瘤成分)和血清肿瘤标志物升高而行右侧腹股沟睾丸切除术。他接受了全身化疗(BEP 方案 x 4 周期),随后肿瘤标志物接近正常。他的化疗后影像学检查显示残留的腹膜后肿块为 6cm,伴有 2 级 IVC 肿瘤血栓,并且肿块怀疑直接侵犯肾下 IVC 壁。患者接受了开放化疗后 RPLND、IVC 血栓切除术、IVC 切除和移植。腹膜后肿块的最终病理报告显示为畸胎瘤,无存活的生殖细胞瘤成分,且手术切缘阴性。他的术中及术后阶段无异常,IVC 移植物通畅,最后一次随访时无疾病复发迹象。

结论

我们展示了首例伴有 IVC 血栓切除术、腔静脉壁切除和移植的化疗后 RPLND 治疗转移性 NSGCT 的手术视频。最终的畸胎瘤病理报告无存活肿瘤,突出了这种病理学的局部血管侵袭潜力。

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引用本文的文献

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Robot-assisted laparoscopic retroperitoneal lymph node dissection with concomitant inferior vena cava thrombectomy for metastatic mixed testicular germ cell cancer: a case report.机器人辅助腹腔镜下后腹膜淋巴结清扫术联合下腔静脉血栓切除术治疗转移性混合性睾丸生殖细胞癌:一例报告
J Med Case Rep. 2019 Aug 27;13(1):272. doi: 10.1186/s13256-019-2200-y.