Scheans Patricia
Legacy Health, Portland, Oregon, USA.
Neonatal Netw. 2012 Mar-Apr;31(2):121-4. doi: 10.1891/0730-0832.31.2.121.
Magnesium sulfate (MgSO4) has been widely used in the perinatal arena for many decades. It has been used for tocolysis in the U.S. for more than 60 years. Estimations of MgSO4 use for preterm labor (less than 34 weeks of gestation) run as high as 80 percent. Magnesium sulfate is a smooth, skeletal, and cardiac muscle depressant. It is used for preterm labor because of its potential to decrease muscle contractility by interfering with calcium uptake in the cells. Thousands of moms and babies have been exposed to this medication even though tocolysis remains an off-label use, the exact mechanism of action is not completely understood, and there are studies that show that it is ineffective for this indication, and no evidence that it improves perinatal outcomes.1-3 Additionally, it is a high alert medication because of its narrow therapeutic window and the risk of causing an immediate life-threatening condition (acute respiratory failure) if an error in administration occurs.4.
几十年来，硫酸镁（MgSO4）一直在围产期领域广泛使用。在美国，它用于抑制宫缩已有60多年历史。据估计，用于早产（妊娠少于34周）的硫酸镁使用率高达80%。硫酸镁是一种平滑肌、骨骼肌和心肌抑制剂。它用于早产是因为其有可能通过干扰细胞对钙的摄取来降低肌肉收缩力。尽管抑制宫缩仍是一种超说明书用药，其确切作用机制尚未完全明确，且有研究表明它对该适应症无效，也没有证据表明它能改善围产期结局，但仍有成千上万的母亲和婴儿接触过这种药物。此外，由于其治疗窗狭窄，且如果给药出现差错会有导致立即危及生命状况（急性呼吸衰竭）的风险，它还是一种高警示药物。
