Department of Medicine, Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Thromb Res. 2012 May;129 Suppl 2(Suppl 2):S70-2. doi: 10.1016/j.thromres.2012.02.038. Epub 2012 Mar 6.
Sickle cell anemia is an inherited hematologic disorder associated with hemolytic and vaso-occlusive complications. An activation of coagulation is also a prominent feature of sickle cell anemia. Growing evidence indicates that coagulation may contribute to the inflammation and vascular injury in sickle cell anemia. This review focuses on tissue factor expression and its contribution to the activation of coagulation, thrombosis and vascular inflammation in sickle cell anemia.
镰状细胞贫血是一种遗传性血液疾病，与溶血性和血管阻塞性并发症有关。凝血的激活也是镰状细胞贫血的一个显著特征。越来越多的证据表明，凝血可能导致镰状细胞贫血中的炎症和血管损伤。本文综述了组织因子表达及其在镰状细胞贫血中凝血激活、血栓形成和血管炎症中的作用。
