Lipe Brea C, Lansigan Frederick, Gui Jiang, Meehan Kenneth
Division of Hematology and Oncology, University of Kansas Medical Center, Westwood, Kansas 66205, USA.
Clin Adv Hematol Oncol. 2012 Jan;10(1):28-32.
This study investigated the impact of prognostic variables, including the distance a patient lives from a transplant center, on the outcome of autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma.
This retrospective analysis included 77 myeloma patients who received an ASCT at Dartmouth Hitchcock Medical Center between 1996 and 2009, 70 of whom were treated between 2002 and 2009. Using linear regression and univariate analysis, we examined the impact of distance from the transplant center on survival. Kaplan-Meier curves identified overall and event-free survival. An association between distance from the transplant center and survival was examined using Cox regression analysis, while adjusting for patient-, disease-, and treatment-related variables.
Increasing distance from the transplant center correlated with improved overall survival (P=.004), but had no impact on disease-free survival (P=.26).
These results suggest that the distance from a transplant center should not be a barrier to ASCT for eligible patients with multiple myeloma.
本研究调查了包括患者居住地与移植中心的距离等预后变量对多发性骨髓瘤自体造血干细胞移植（ASCT）结局的影响。
这项回顾性分析纳入了1996年至2009年间在达特茅斯希区柯克医疗中心接受ASCT的77例骨髓瘤患者，其中70例在2002年至2009年间接受治疗。我们使用线性回归和单变量分析，研究了与移植中心的距离对生存的影响。Kaplan-Meier曲线确定了总生存率和无事件生存率。在对患者、疾病和治疗相关变量进行校正的同时，使用Cox回归分析研究了与移植中心的距离和生存之间的关联。
与移植中心的距离增加与总生存率提高相关（P = 0.004），但对无病生存率无影响（P = 0.26）。
这些结果表明，对于符合条件的多发性骨髓瘤患者，与移植中心的距离不应成为ASCT的障碍。
