Yamashita Hiroko, Asazuma Naoki, Nakamura Hiroshi, Igarashi Hiroaki, Machinami Rikuo, Ogata Itsuro
Department of Gastroenterology and Hepatology, Kawakita General Hospital, Japan.
Nihon Shokakibyo Gakkai Zasshi. 2012 Mar;109(3):400-7.
A very elderly patient with primary non-Hodgkin lymphoma of the esophagus is reported. An 87-year-old woman presented with dysphagia. Endoscopy revealed an elevated lesion with ulceration in the middle and lower esophagus. Endoscopic biopsy demonstrated pathological diagnosis and immunochemistry typical of non-Hodgkin lymphoma (Ann Arbor stage IIIEA), diffuse large B-cell lymphoma on the WHO classification. Systemic chemotherapy with 6 courses of a 50% dose of R-CHOP followed by 8 courses of rituximab for maintenance, successfully resulted in complete remission. Complete remission has been maintained for 58 months.
报告了一例患有原发性食管非霍奇金淋巴瘤的高龄患者。一名87岁女性因吞咽困难就诊。内镜检查发现食管中下段有一个伴有溃疡的隆起性病变。内镜活检显示为非霍奇金淋巴瘤的病理诊断及免疫组化结果（Ann Arbor分期IIIEA期），按照世界卫生组织分类为弥漫性大B细胞淋巴瘤。采用6个疗程50%剂量的R-CHOP方案进行全身化疗，随后使用利妥昔单抗进行8个疗程的维持治疗，成功实现了完全缓解。完全缓解状态已维持58个月。
