Department of Chemistry, University of Leicester, Leicester, LE1 7RH, UK.
Chem Commun (Camb). 2012 Apr 18;48(31):3709-11. doi: 10.1039/c2cc30295k. Epub 2012 Mar 7.
A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.
一种模拟肽 β-折叠的合成支架已经基于苯并二氢恶唑啉寡聚体设计和合成。该寡聚体的构象偏好使用分子建模和溶液 NMR 实验进行了研究，表明其具有平面构象，可准确模拟肽 β-折叠的 i、i+2 和 i+4 残基。
