Gladwin A M, Trowbridge E A, Slater D N, Reardon D, Martin J F
Department of Medicine, Royal Hallamshire Hospital, Sheffield, South Yorkshire, U.K.
Am J Hematol. 1990 Dec;35(4):225-31. doi: 10.1002/ajh.2830350402.
Platelet counts were measured routinely in 718 volunteer blood donors and 124 patients with malignant lymphoma. When considered by gender, the mean platelet counts of the patients with malignant lymphoma were significantly increased when compared to controls (P less than 0.01). In addition, 9% of males and 4% of females with lymphoma exhibited a thrombocytosis, in which their platelet counts exceeded the upper limit of the normal platelet count for control subjects (defined as 2 SDs in excess of the mean value). Megakaryocyte whole size, cytoplasmic and nuclear sizes, and megakaryocyte numbers were also quantified in bone marrow obtained from the iliac crest of 5 hematologically normal subjects and 26 patients with malignant lymphoma. Mean megakaryocyte sizes were significantly greater in subjects with lymphoma, when compared to control values (P less than 0.05). No significant differences in megakaryocyte numbers in bone marrow were observed between the two groups. For subjects with malignant lymphoma, platelet count was found to be significantly positively correlated with megakaryocyte size. The results of this study suggest that the elevated platelet count associated with malignant lymphoma is mediated by an increase in the size of the megakaryocytes in the bone marrow.
对718名志愿献血者和124例恶性淋巴瘤患者进行了血小板计数的常规检测。按性别分析，恶性淋巴瘤患者的平均血小板计数与对照组相比显著升高（P<0.01）。此外，9%的男性淋巴瘤患者和4%的女性淋巴瘤患者出现血小板增多症，其血小板计数超过了对照受试者正常血小板计数的上限（定义为超过平均值2个标准差）。还对5名血液学正常受试者和26例恶性淋巴瘤患者髂嵴骨髓中的巨核细胞整体大小、细胞质和细胞核大小以及巨核细胞数量进行了量化。与对照值相比，淋巴瘤患者的平均巨核细胞大小显著更大（P<0.05）。两组之间骨髓中巨核细胞数量未观察到显著差异。对于恶性淋巴瘤患者，发现血小板计数与巨核细胞大小显著正相关。本研究结果表明，与恶性淋巴瘤相关的血小板计数升高是由骨髓中巨核细胞大小增加介导的。
