Research and Development, Diabetes Division, Sanofi-Aventis Deutschland GmbH, Frankfurt/M, Germany.
Horm Metab Res. 2012 Apr;44(4):273-8. doi: 10.1055/s-0032-1304581. Epub 2012 Mar 7.
Adipose tissue (AT) inflammation is linked to the pathogenesis of diabetes in obesity. Here, we compare the AT inflammatory state of 2 animal models of obesity and obesity plus diabetes, respectively. Obese nondiabetic ZF rats exhibited a trend towards increased proportions of CD11b positive cells in the adipose tissue stroma vascular fraction suggesting a state of increased AT inflammation compared to their lean littermates, but no alterations in systemic inflammatory parameters. In contrast, obese diabetic ZDF rats exhibited systemic as well as local AT inflammation with elevated levels of circulating Regulated upon Activation, Normal T-cell Expressed and Secreted Protein (Rantes), interleukin 1β (IL-1β) and monocyte chemotactic protein 1 (MCP-1), and an increased infiltration of adipose tissue CD11b positive cells. Our data provide a novel phenotypic characterisation of 2 common metabolic animal models and suggest an association of obesity with local inflammation in adipose tissue, and an association of diabetes with local inflammation in adipose tissue plus systemic inflammation. AT inflammation in obesity might therefore initiate a process that above a certain limits finally results in systemic inflammation and diabetes.
脂肪组织（AT）炎症与肥胖症中的糖尿病发病机制有关。在这里，我们分别比较了两种肥胖症和肥胖症合并糖尿病动物模型的 AT 炎症状态。肥胖但非糖尿病的 ZF 大鼠的脂肪组织基质血管部分中 CD11b 阳性细胞的比例呈增加趋势，这表明与它们的瘦同胞相比，处于 AT 炎症增加的状态，但全身炎症参数没有改变。相比之下，肥胖的糖尿病 ZDF 大鼠表现出全身性和局部 AT 炎症，循环调节活化正常 T 细胞表达和分泌蛋白（Rantes）、白细胞介素 1β（IL-1β）和单核细胞趋化蛋白 1（MCP-1）水平升高，脂肪组织 CD11b 阳性细胞浸润增加。我们的数据为两种常见的代谢性动物模型提供了新的表型特征，并表明肥胖与脂肪组织的局部炎症有关，而糖尿病与脂肪组织的局部炎症和全身性炎症有关。因此，肥胖症中的 AT 炎症可能会引发一个过程，当超过一定限度时，最终会导致全身性炎症和糖尿病。
