Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Ren Fail. 2012;34(5):649-52. doi: 10.3109/0886022X.2012.664508. Epub 2012 Mar 8.
Necrotizing fasciitis is an uncommon complication of nephrotic syndrome. There have been only four cases of necrotizing fasciitis complicating nephrotic syndrome reported in the English literature. We report a 40-year-old woman with minimal-change nephrotic syndrome receiving cyclosporine therapy, who suffered from necrotizing fasciitis of her left leg. Cultures of blood and surgical specimens yielded Serratia marcescens. Despite aggressive treatment, the patient expired shortly after surgery. We review the literature and find eight cases of necrotizing fasciitis caused by S. marcescens. Most of these patients had an immunocompromised background, and the mortality rate was high.
坏死性筋膜炎是肾病综合征的一种罕见并发症。仅有 4 例坏死性筋膜炎合并肾病综合征的病例在英文文献中报道过。我们报告了一例 40 岁的女性，患有微小病变性肾病综合征，接受环孢素治疗，发生了左侧腿部的坏死性筋膜炎。血液和手术标本的培养均产生了粘质沙雷氏菌。尽管进行了积极的治疗，患者在手术后不久还是去世了。我们对文献进行了回顾，发现了 8 例由粘质沙雷氏菌引起的坏死性筋膜炎的病例。这些患者大多存在免疫功能低下的背景，死亡率很高。
