Department of Diagnostic Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1, Dongcheng District, Beijing 100730, China.
Eur J Radiol. 2012 Nov;81(11):3185-9. doi: 10.1016/j.ejrad.2012.01.029. Epub 2012 Mar 7.
To prospectively study the ultrasound-guided near-infrared diffuse optical tomography (DOT) findings of the total haemoglobin concentration (THC) detected in invasive breast carcinomas and its contribution to the prediction of axillary lymph node (LN) status.
A total of 195 invasive breast carcinomas were prospectively studied with DOT before surgery. Lumpectomy or mastectomy with full axillary nodal dissection was performed. Tumour size and THC level were correlated with LN status by a logistic regression analysis.
One hundred twenty-four patients (63.59%) was LN(-) and 71 (36.41%) was LN(+). The average THC was significantly higher in the LN(+) group than in the LN(-) group (252.94±69.19 μmol/L versus 203.86±83.13 μmol/L, P=0.01). A multivariate analysis showed an independent relationship between the probability of axillary metastasis, elevated THC level (P=0.01), and tumour size (P=0.001). The odds ratio with THC≥140 μmol/L was 13.651 (1.781-104.560), whereas that of tumour size with a 1cm increment was only 1.777 (1.283-2.246).
The THC level and the tumour size are independent and preoperative predictors of axillary nodal status; these variables may improve the diagnosis of patients with lymph node metastasis.
前瞻性研究浸润性乳腺癌中总血红蛋白浓度（THC）的超声引导近红外漫射光学断层扫描（DOT）检测结果，并探讨其对腋窝淋巴结（LN）状态预测的作用。
对 195 例浸润性乳腺癌患者在术前进行 DOT 检查。行保乳或乳房切除术并进行腋窝淋巴结清扫。通过逻辑回归分析，将肿瘤大小和 THC 水平与 LN 状态相关联。
124 例（63.59%）患者为 LN（-），71 例（36.41%）患者为 LN（+）。LN（+）组的平均 THC 明显高于 LN（-）组（252.94±69.19 μmol/L 比 203.86±83.13 μmol/L，P=0.01）。多变量分析显示，腋窝转移的概率、升高的 THC 水平（P=0.01）和肿瘤大小（P=0.001）之间存在独立关系。THC≥140 μmol/L 的优势比为 13.651（1.781-104.560），而肿瘤大小每增加 1cm 的优势比仅为 1.777（1.283-2.246）。
THC 水平和肿瘤大小是腋窝淋巴结状态的独立且术前预测因子；这些变量可能改善对淋巴结转移患者的诊断。
