Medical Biochemistry Department, Zagazig University, Zagazig, Egypt.
Cell Immunol. 2012;274(1-2):34-8. doi: 10.1016/j.cellimm.2012.02.006. Epub 2012 Feb 17.
The aim of the study was to investigate whether polymorphisms in genes encoding Toll-like receptors (TLR2 and TLR4) may modify relative risk for development of asthma or allergic rhinitis. The results showed that the genotype and allele frequencies of the TLR2 Arg753Gln and TLR4 Asp299Gly polymorphisms were not significantly different between asthmatic children or allergic rhinitis when compared to controls (p>0.05 for each) or even when compared further with IgE level. However, it was shown that the mutant allele of TLR2 or TLR4 polymorphisms were significantly associated with the moderate-severe group compared to the mild group in both atopic asthmatics and allergic rhinitis group (p>0.001 for each). In conclusion, our study demonstrates a lack of association of TLR2 and TLR4 polymorphisms with asthma and allergic rhinitis but suggests significant association between these genetic variants and the disease severity.
本研究旨在探讨 Toll 样受体（TLR2 和 TLR4）基因编码区多态性是否可能改变哮喘或过敏性鼻炎的发病相对风险。结果表明，与对照组相比（p＞0.05），哮喘儿童或过敏性鼻炎患者 TLR2 Arg753Gln 和 TLR4 Asp299Gly 多态性的基因型和等位基因频率无显著差异，甚至与 IgE 水平相比亦无显著差异。然而，我们发现与轻症组相比，TLR2 或 TLR4 多态性的突变等位基因在特应性哮喘和过敏性鼻炎组的中重度组中与疾病严重程度显著相关（p＞0.001）。总之，我们的研究表明 TLR2 和 TLR4 多态性与哮喘和过敏性鼻炎无关，但提示这些遗传变异与疾病严重程度之间存在显著关联。
