INSERM, U848, IGR, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.
EMBO Rep. 2012 Apr 2;13(4):322-30. doi: 10.1038/embor.2012.19.
During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.
在过去的二十年中，细胞凋亡已经成为了一个研究热潮，导致了多个基因产物的发现，这些产物调控着细胞凋亡的诱导和执行。同时，逐渐明显的是，即使不是所有，最初因在细胞凋亡中具有重要作用而被发现的大多数蛋白质也介导了广泛的非细胞凋亡功能。一方面，凋亡调节剂和执行者参与了细胞周期进程、分化、代谢、自噬和炎症等多种非致死性生理过程。另一方面，促凋亡蛋白可以控制其他形式的程序性细胞死亡，特别是调节性细胞坏死。在这篇综述中，我们从功能的角度总结了凋亡核心机制的非传统作用，并讨论了它们的病理生理学意义。
