Lautenberg Center for Immunology, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Nat Immunol. 2011 Jul 19;12(8):715-23. doi: 10.1038/ni.2060.
Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.
炎症是一种基本的保护反应，但有时会出现异常，成为许多慢性人类疾病（包括癌症）发病机制的主要协同因子。在这里，我们回顾了转录因子 NF-κB 在炎症和癌症中的进化关系和相反功能。尽管 NF-κB 在许多类型的癌症中似乎发挥了明显的促进肿瘤作用，但它在某些肿瘤中具有混淆作用。了解 NF-κB 在肿瘤发生中的活性和功能对于成功控制其活性至关重要，这是现代癌症生物学的一个重要挑战。
