Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Inflamm Res. 2012 Jun;61(6):635-41. doi: 10.1007/s00011-012-0455-5. Epub 2012 Mar 9.
The aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations.
The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and RA susceptibility.
A total of ten comparative studies were included in this meta-analysis, which showed an association between the two allele of rs6920220 and RA in all study subjects [odds ratio (OR) 1.216, 95% confidence interval (CI) 1.166-1.269, p < 1.0 × 10(-9)]. The two allele of rs6920220 was also significantly associated with RA in Europeans only (OR 1.227, 95% CI 1.175-1.282, p < 1.0 × 10(-9)). Meta-analysis revealed no association between the two allele of the rs10499194 polymorphism and RA in Europeans, but a significant association was found in Asians (OR 1.254, 95% CI 1.101-1.429, p=6.7 × 10(-4)). Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214-2.331, p=1.9 × 10(-6)).
This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
本研究旨在确定肿瘤坏死因子-α诱导蛋白 3（TNFAIP3）多态性是否与不同种族人群的类风湿关节炎（RA）易感性相关。
作者对 TNFAIP3 多态性与 RA 易感性的关联进行了荟萃分析。
本荟萃分析共纳入 10 项研究，结果显示 rs6920220 两个等位基因与所有研究对象的 RA 相关（比值比 [OR] 1.216，95%置信区间 [CI] 1.166-1.269，p<1.0×10(-9)）。rs6920220 两个等位基因在欧洲人群中也与 RA 显著相关（OR 1.227，95%CI 1.175-1.282，p<1.0×10(-9)）。荟萃分析显示 rs10499194 多态性两个等位基因与欧洲人群的 RA 无关，但在亚洲人群中存在显著相关性（OR 1.254，95%CI 1.101-1.429，p=6.7×10(-4)）。此外，rs2230926 两个等位基因与所有研究对象的 RA 相关（OR 1.390，95%CI 1.214-2.331，p=1.9×10(-6)）。
本荟萃分析证实，TNFAIP3 多态性与不同种族人群的 RA 易感性相关，即 rs6920220 与欧洲人群相关，rs10499194 与亚洲人群相关。
