Bilateral subdural hemorrhage as a serious adverse event of dasatinib in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia.

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作者信息

Yhim Ho-Young, Kim Hee Sun, Lee Na-Ri, Song Eun-Kee, Kwak Jae-Yong, Yim Chang-Yeol

出版信息

Int J Hematol. 2012 May;95(5):585-7. doi: 10.1007/s12185-012-1045-6. Epub 2012 Mar 9.

DOI:10.1007/s12185-012-1045-6

PMID:22403059

Abstract

摘要

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Bilateral subdural hemorrhage as a serious adverse event of dasatinib in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia.

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Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia.达沙替尼与伊马替尼治疗新诊断的慢性期慢性髓性白血病。

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The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo.新型酪氨酸激酶抑制剂及抗癌药物达沙替尼在体外和体内均可可逆地影响血小板活化。

Blood. 2009 Aug 27;114(9):1884-92. doi: 10.1182/blood-2009-02-205328. Epub 2009 Jun 3.

Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia.酪氨酸激酶抑制剂诱发慢性髓性白血病患者的血小板功能障碍。

Blood. 2009 Jul 9;114(2):261-3. doi: 10.1182/blood-2008-09-180604. Epub 2009 May 4.

Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up.达沙替尼140毫克每日一次与70毫克每日两次用于对伊马替尼耐药或不耐受的加速期慢性髓性白血病患者的3期研究：15个月中位随访

Blood. 2009 Jun 18;113(25):6322-9. doi: 10.1182/blood-2008-11-186817. Epub 2009 Apr 15.

Bleeding diathesis in patients with chronic myelogenous leukemia receiving dasatinib therapy.接受达沙替尼治疗的慢性粒细胞白血病患者的出血素质

Cancer. 2009 Jun 1;115(11):2482-90. doi: 10.1002/cncr.24257.

Metabolism and disposition of dasatinib after oral administration to humans.达沙替尼口服给药后在人体内的代谢与处置。

Drug Metab Dispos. 2008 Jul;36(7):1357-64. doi: 10.1124/dmd.107.018267. Epub 2008 Apr 17.

Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate.施达赛用于治疗对甲磺酸伊马替尼耐药或不耐受的慢性髓性白血病和费城染色体阳性的急性淋巴细胞白血病。

Clin Cancer Res. 2008 Jan 15;14(2):352-9. doi: 10.1158/1078-0432.CCR-07-4175.

Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study.达沙替尼可使对伊马替尼耐药或不耐受的费城染色体阳性成人急性淋巴细胞白血病患者迅速获得血液学和细胞遗传学缓解：一项2期研究的中期结果。

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