Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Cancer Sci. 2012 Jun;103(6):1084-9. doi: 10.1111/j.1349-7006.2012.02265.x. Epub 2012 Apr 19.
Expression cloning was used to initially isolate the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene as a suppressor of transformation. The gene was found to encode a membrane-anchored regulator of MMPs. Experimental studies showed that RECK can suppress tumor invasion, metastasis, and angiogenesis. However, the clinical impact of RECK remains unclear. To assess the clinical significance of RECK expression in invasive breast cancer, a total of 119 patients with invasive breast cancer were retrospectively examined. Expression of RECK in tumor tissues was assessed by immunohistochemical staining. A significant correlation between RECK expression and 5-year survival rate was documented. The 5-year survival rate for patients with strong RECK expression was significantly higher than that for patients with weakly expressing tumors. Univariate and multivariate analyses confirmed that reduced RECK expression was an independent and significant factor in predicting a poor prognosis. In conclusion, RECK expression is a significant prognostic factor correlated with long-term survival for patients with invasive breast cancer. RECK expression is therefore a potentially useful prognostic marker for breast cancer.
采用表达克隆的方法，最初分离出具有 Kazal 基序的反转诱导富含半胱氨酸的蛋白（RECK）基因作为转化的抑制剂。该基因编码一种 MMPs 的膜锚定调节剂。实验研究表明，RECK 可抑制肿瘤侵袭、转移和血管生成。然而，RECK 的临床意义尚不清楚。为了评估 RECK 在浸润性乳腺癌中的表达的临床意义，对 119 例浸润性乳腺癌患者进行了回顾性检查。通过免疫组织化学染色评估 RECK 在肿瘤组织中的表达。记录到 RECK 表达与 5 年生存率之间存在显著相关性。RECK 表达强的患者的 5 年生存率明显高于肿瘤表达弱的患者。单因素和多因素分析证实，RECK 表达减少是预测预后不良的独立和显著因素。总之，RECK 表达是与浸润性乳腺癌患者长期生存相关的重要预后因素。因此，RECK 表达是乳腺癌潜在的有用预后标志物。
