Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Helicobacter. 2012 Apr;17(2):107-15. doi: 10.1111/j.1523-5378.2011.00916.x.
Helicobacter pylori-infected children from coastal Tumaco, Colombia, have more parasitism, and adults have lower gastric cancer risk compared with high-altitude Pasto/Tuquerres residents. Because helminth and Toxoplasma gondii infections alter helicobacter gastritis in rodent models, we determined whether seropositivity to Ascaris lumbricoides or T. gondii was associated with Th2-IgG1 or Th1-IgG2 responses to H. pylori.
Sera (240) from the two populations were evaluated for A. lumbricoides and T. gondii seropositivity and results correlated with IgE and IgG isotype responses to H. pylori.
Most Tumaco children and adults were seropositive for A. lumbricoides (89%, 66%), T. gondii (59%, 98%), or both (45%, 66%). In contrast, seropositivity among Pasto/Tuquerres children was much lower (9%A. lumbricoides, 11%T. gondii, and 2% dual positive) but increased in adults (58%A. lumbricoides, 82%T. gondii, and 41% dual positive). A. lumbricoides seropositivity correlated with elevated IgE and anti-inflammatory Th2-IgG1 responses to H. pylori, while T. gondiigondii seropositivity was linked to elevated IgE, pro-inflammatory Th1-IgG2, IgG3, and IgG4 responses to H. pylori. Individuals with high T. gondii titers had reduced Th1-IgG2, IgG3, and IgG4 responses to H. pylori.
Results support regional differences for childhood parasitism and indicate A. lumbricoides and T. gondii infections may impact inflammatory responses to H. pylori and partially explain differences in gastric cancer risk in Colombia.
与高海拔帕斯托/图尔奎雷斯居民相比，来自哥伦比亚沿海图马科的感染幽门螺杆菌的儿童寄生虫感染更多，而成年人患胃癌的风险较低。由于蠕虫和弓形虫感染改变了啮齿动物模型中的幽门螺杆菌胃炎，我们确定对蛔虫或弓形虫的血清阳性是否与对幽门螺杆菌的 Th2-IgG1 或 Th1-IgG2 反应有关。
评估来自两个群体的 240 份血清，以确定是否存在蛔虫和弓形虫血清阳性，并将结果与对幽门螺杆菌的 IgE 和 IgG 同种型反应相关联。
大多数图马科儿童和成人的蛔虫（89%，66%），弓形虫（59%，98%）或两者（45%，66%）血清阳性。相比之下，帕斯托/图尔奎雷斯儿童的血清阳性率要低得多（蛔虫 9%，弓形虫 11%，双重阳性 2%），但在成年人中却有所增加（蛔虫 58%，弓形虫 82%，双重阳性 41%）。蛔虫血清阳性与对幽门螺杆菌的升高 IgE 和抗炎性 Th2-IgG1 反应相关，而弓形虫血清阳性与升高的 IgE、促炎性 Th1-IgG2、IgG3 和 IgG4 反应相关。高弓形虫滴度的个体对幽门螺杆菌的 Th1-IgG2、IgG3 和 IgG4 反应降低。
结果支持儿童寄生虫病的地区差异，并表明蛔虫和弓形虫感染可能影响对幽门螺杆菌的炎症反应，并部分解释了哥伦比亚胃癌风险的差异。
