Makatsariia A D, Prosviriakova I G, Mishchenko A L, Kazakova L A
Akush Ginekol (Mosk). 1990 Jul(7):31-5.
Pregnancy in patients with a history of thrombotic complications puts them at a great risk of thrombosis and obstetric complications (hypoxia, intrauterine hypotrophy, bleedings). Functional strain of the hemostasis system occurs at the onset of pregnancy in women with a history of thrombotic complications without clinical symptoms of thrombosis. The incidence of disseminated intravascular coagulation with activation of both pro-coagulation and platelet-mediated hemostasis is 33% and that with activation of only platelet-mediated hemostasis is 64%. Differential use of antithrombotic drugs prevents thrombosis recurrence in 98% of patients.
有血栓形成并发症病史的患者怀孕会使其面临血栓形成和产科并发症（缺氧、宫内发育迟缓、出血）的巨大风险。有血栓形成并发症病史但无血栓形成临床症状的女性在怀孕初期会出现止血系统的功能应激。同时激活凝血和血小板介导的止血的弥散性血管内凝血发生率为33%，仅激活血小板介导的止血的发生率为64%。差异化使用抗血栓药物可使98%的患者预防血栓复发。
