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成功应用达托霉素治疗法布里-安德森病合并肾移植后耐甲氧西林金黄色葡萄球菌骨髓炎

Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant Staphylococcus aureus in a renal transplant recipient with Fabry-Anderson disease.

机构信息

Microbiology and Virology Unit, Pescara General Hospital, Pescara, Italy.

出版信息

Ann Clin Microbiol Antimicrob. 2012 Mar 11;11:6. doi: 10.1186/1476-0711-11-6.

DOI:10.1186/1476-0711-11-6
PMID:22404900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3324387/
Abstract

Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to first-line Teicoplanin and second-line Tigecycline, whereas he was successfully treated with third-line Daptomycin monotherapy at 4 mg/Kg/qd for 4 weeks. Local debridement was performed in advance of each line of treatment.

摘要

达托霉素在成人中被批准用于治疗金黄色葡萄球菌耐甲氧西林感染，包括骨骼和皮肤复杂感染。我们首次描述了其在一名法布里-安德森病合并右跟骨骨髓炎的肾移植受者中的应用。该患者对一线替考拉宁和二线替加环素均无反应，而三线达托霉素单药治疗（4 毫克/公斤/天，共 4 周）则取得了成功。在每一线治疗之前都进行了局部清创。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/3324387/4ca73e79e8c3/1476-0711-11-6-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/3324387/3b971735fedd/1476-0711-11-6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/3324387/4ca73e79e8c3/1476-0711-11-6-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/3324387/3b971735fedd/1476-0711-11-6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/3324387/4ca73e79e8c3/1476-0711-11-6-2.jpg

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