Ellis F R, Halsall P J, Christian A S
University Department of Anaesthesia, St. James's University Hospital, Leeds.
Anaesthesia. 1990 Oct;45(10):838-41. doi: 10.1111/j.1365-2044.1990.tb14566.x.
As anaesthetists have become more aware of malignant hyperthermia the mortality rate has fallen, but concommitantly the number of dubious and aborted cases has increased. All probands who developed a suspected malignant hyperthermia reaction during anaesthesia and subsequently underwent muscle biopsy were classified according to the clinical presentation. A probability for malignant hyperthermia can be calculated, using the classification, for each type of clinical presentation; this varied from 0.96 to 0.07. Certain clinical features were found to be of more value as predictors than others; these included a high creative kinase and myoglobinuria. The accuracy of prediction depends on a clear contemporaneous description of the clinical events.
随着麻醉医生对恶性高热的认识不断提高，死亡率有所下降，但与此同时，可疑和未确诊病例的数量却有所增加。所有在麻醉期间出现疑似恶性高热反应并随后接受肌肉活检的先证者均根据临床表现进行分类。利用该分类，可针对每种临床表现计算出恶性高热的发生概率；其范围从0.96到0.07不等。结果发现，某些临床特征作为预测指标比其他特征更具价值；这些特征包括高肌酸激酶和肌红蛋白尿。预测的准确性取决于对临床事件清晰的同步描述。
