Nδ-乙酰基-Nδ-羟基鸟氨酸类似物的合成与应用：去铁福林新型金属配合物的鉴定。
Synthesis and application of an Nδ-acetyl-Nδ-hydroxyornithine analog: identification of novel metal complexes of deferriferrichrysin.
机构信息
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
Bioorg Med Chem. 2012 Apr 15;20(8):2651-5. doi: 10.1016/j.bmc.2012.02.033. Epub 2012 Feb 20.
PMID:22405596
Abstract
Synthesis of Fmoc-protected N(δ)-acetyl-N(δ)-(tert-butoxy)-l-ornithine has revealed it to be a metal-chelating amino-acid precursor. This protected amino acid was compatible with the preparation of ferrichrome peptides by standard Fmoc-based solid-phase peptide synthesis. Evaluation of deferriferrichrysin for metal ion chelation revealed that zirconium(IV) and titanium(IV) formed complexes with deferriferrichrysin.
摘要
合成 Fmoc-保护的 N(δ)-乙酰基-N(δ)-(叔丁氧基)-l-鸟氨酸表明它是一种金属螯合氨基酸前体。这种保护氨基酸与基于 Fmoc 的固相肽合成标准制备铁载体肽兼容。对去铁铁菌红素的金属离子螯合评估表明，锆(IV)和钛(IV)与去铁铁菌红素形成配合物。
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