Loos G, Paulon R, Verrelle P, Lapeyre M
Département de radiothérapie, centre Jean-Perrin, Clermont-Ferrand, France.
Cancer Radiother. 2012 Apr;16(2):136-9. doi: 10.1016/j.canrad.2011.11.002. Epub 2012 Mar 9.
In the treatment of brain metastases, whole brain radiotherapy can be carried out according two distinct methods: one using multileaf collimator for field shaping and protection of organs at risk, and a second one is to make a rotation of the field to avoid the eyes. The aim of the study was to compare for 10 patients the dose distributions at organs at risk for each method. Patients received 30 Gy in 10 fractions. Except for parotid glands, the dose received by organs at risk and the planning target volume was the same with each method. For whole brain radiotherapy, excluding the cisterna cerebellomedullaris, the mean parotid dose was 9.63 Gy using the multileaf collimator versus 12.32 Gy using the field rotation (P=0.04). For whole brain radiotherapy including the cisterna cerebellomedullaris, the mean parotid dose was 11.12 Gy using the multileaf collimator versus 20.06 Gy using field rotation (P<0.001). Using the multileaf collimator seems recommended for whole brain radiotherapy, to reduce the dose to the parotids.
在脑转移瘤的治疗中,全脑放疗可根据两种不同方法进行:一种是使用多叶准直器进行射野塑形并保护危及器官,另一种是旋转射野以避开眼睛。本研究的目的是比较10例患者每种方法在危及器官处的剂量分布。患者接受10次分割共30 Gy的照射。除腮腺外,每种方法在危及器官和计划靶体积处接受的剂量相同。对于全脑放疗,不包括小脑延髓池时,使用多叶准直器时腮腺平均剂量为9.63 Gy,而使用射野旋转时为12.32 Gy(P = 0.04)。对于包括小脑延髓池的全脑放疗,使用多叶准直器时腮腺平均剂量为11.12 Gy,而使用射野旋转时为20.06 Gy(P < 0.001)。全脑放疗似乎推荐使用多叶准直器,以减少腮腺的剂量。