Department of Gynecology and Obstetrics, Cumhuriyet University School of Medicine, Sivas, Turkey.
J Investig Med. 2012 Jun;60(5):813-7. doi: 10.2310/JIM.0b013e31824e9900.
Polycystic ovary syndrome (PCOS) is a frequent reproductive and metabolic disorder associated with insulin resistance. Recently, angiopoietins were identified in the systemic circulation and have been designated angiopoietinlike proteins (ANGPTL). More recently, it is shown that angiopoietin-related growth factor (AGF, also called ANGPTL6) directly regulate lipid, glucose, and energy metabolism independent of angiogenic effects in animal studies. The aim of this study was to determine whether there is an association between AGF and PCOS.
The study included 55 [corrected] patients with PCOS and 30 healthy control women. We analyzed serum levels of AGF and other biochemical and anthropometric markers in all the subjects.
This study showed that serum AGF levels were significantly higher in the subjects with PCOS (102.28 ng/mL) than those in the healthy control group (63.08 ng/mL; P < 0.001). Body mass index (24.33 vs 22.11 kg/m; P = 0.017), free testosterone (2.81 vs 2.17 pmol/L; P = 0.009), androstenedione (3.28 vs 2.92 nmol/L; P = 0.033), 17-hydroxyprogesterone (2.72 vs 2.09 ng/mL; P = 0.039), homeostasis model of assessment-insulin resistance (2.65 vs 1.9; P = 0.016), and fasting glucose (107.09 vs 96.18 mmol/L; P = 0.001) were found significantly higher in PCOS group than in control group. But there was no correlation between AGF and these parameters in PCOS group. In addition, no correlation between the AGF and other distinctive features of PCOS was found.
Serum AGF levels were paradoxically increased in patients with PCOS in comparison with data of animal experiments. Further studies are needed to better elucidate the physiologic significance of circulating AGF in human disease.
多囊卵巢综合征（PCOS）是一种常见的生殖和代谢疾病，与胰岛素抵抗有关。最近，血管生成素在全身循环中被发现，并被指定为血管生成素样蛋白（ANGPTL）。最近，研究表明血管生成素相关生长因子（AGF，也称为 ANGPTL6）在动物研究中独立于血管生成作用直接调节脂质、葡萄糖和能量代谢。本研究旨在确定 AGF 与 PCOS 是否存在关联。
本研究纳入了 55 例 PCOS 患者和 30 名健康对照女性。我们分析了所有受试者的血清 AGF 水平和其他生化及人体测量标志物。
本研究显示，PCOS 患者的血清 AGF 水平（102.28ng/ml）明显高于健康对照组（63.08ng/ml；P<0.001）。体重指数（24.33 与 22.11kg/m；P=0.017）、游离睾酮（2.81 与 2.17pmol/L；P=0.009）、雄烯二酮（3.28 与 2.92nmol/L；P=0.033）、17-羟孕酮（2.72 与 2.09ng/ml；P=0.039）、稳态模型评估-胰岛素抵抗（2.65 与 1.9；P=0.016）和空腹血糖（107.09 与 96.18mmol/L；P=0.001）在 PCOS 组中明显高于对照组。但在 PCOS 组中，AGF 与这些参数之间无相关性。此外，AGF 与 PCOS 的其他特征之间也没有相关性。
与动物实验数据相比，PCOS 患者的血清 AGF 水平异常升高。需要进一步研究以更好地阐明循环 AGF 在人类疾病中的生理意义。
