对邻异丙基苯乙酸酯的香料物质评估。
Fragrance material review on p-isopropylbenzyl acetate.
机构信息
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
出版信息
Food Chem Toxicol. 2012 Sep;50 Suppl 2:S394-7. doi: 10.1016/j.fct.2012.02.060. Epub 2012 Mar 3.
A toxicologic and dermatologic review of p-isopropylbenzyl acetate when used as a fragrance ingredient is presented. p-Isopropylbenzyl acetate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1 to 4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for p-isopropylbenzyl acetate were evaluated, then summarized, and includes: physical properties, acute toxicity, skin irritation, and skin sensitization data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.
当用作香料成分时，对 p-异丙基苄基乙酸酯的毒理学和皮肤学评估进行了介绍。p-异丙基苄基乙酸酯是芳基烷基醇单酸酯（AAASAE）香料结构基团的成员。AAASAE 香料成分是通过芳基烷基醇与简单羧酸（1 至 4 个碳原子的链）反应生成甲酸盐、乙酸盐、丙酸盐、丁酸盐、异丁酸酯和碳酸盐酯而制备的。本综述包含了与该特定香料成分相关的所有可用毒理学和皮肤学论文的详细摘要，并非独立文件。对 p-异丙基苄基乙酸酯的现有数据进行了评估、总结，包括：物理性质、急性毒性、皮肤刺激和皮肤致敏数据。将与本文件同时发布对整个 AAASAE 的安全性评估。有关该材料和所有 AAASAE 在香料中的安全使用的全面评估，请参见 Belsito 等人（2012 年）。
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