Remotti Helen Elaine, Winner Megan, Saif Muhammad Wasif
Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY 10032, USA.
JOP. 2012 Mar 10;13(2):135-8.
Intraductal papillary mucinous neoplasms (IPMNs) are a heterogeneous group of mucin producing cystic tumors that involve the main pancreatic duct and/or branch ducts and may be associated with invasive carcinoma. Predicting the risk of malignant transformation of an IPMN lesion can be challenging. The Sendai criteria, based in large part on radiographic imaging features, help guide surgical intervention based on the stratification of cysts into high and low risk lesions for malignancy. Invasive carcinoma may develop in the index IPMN lesion or in a separate site within the pancreas, supporting the concept of a field defect in IPMN tumorigenesis. This stresses the importance of evaluation of the entire pancreas upon diagnosis of IPMN and continued surveillance of the residual pancreas following resection. Herein, the authors summarize the data presented at the 2012 ASCO Gastrointestinal Cancers Symposium regarding prevalence and site of invasive carcinoma detected in patients undergoing surveillance for IPMN (Abstract #152).
导管内乳头状黏液性肿瘤（IPMNs）是一组异质性的产生黏液的囊性肿瘤，累及主胰管和/或分支胰管，且可能与浸润性癌相关。预测IPMN病变发生恶性转化的风险可能具有挑战性。仙台标准很大程度上基于影像学特征，有助于根据囊肿分为恶性高风险和低风险病变来指导手术干预。浸润性癌可能在索引IPMN病变中发生，也可能在胰腺内的另一个部位发生，这支持了IPMN肿瘤发生中存在场缺陷的概念。这强调了在诊断IPMN时评估整个胰腺以及在切除术后持续监测残余胰腺的重要性。在此，作者总结了在2012年美国临床肿瘤学会（ASCO）胃肠道癌症研讨会上所展示的关于接受IPMN监测的患者中浸润性癌的患病率和发生部位的数据（摘要#152）。
