Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, China.
Neurol India. 2012 Jan-Feb;60(1):29-35. doi: 10.4103/0028-3886.93585.
There are currently few published studies that compare hippocampal volume (HCV) in children with temporal lobe epilepsy (TLE). Aims : T0 o compare HCVs in children with TLE and in relation to normal controls (NC), and to analyze HCV change in the acute phase in pediatric subjects using magnetic resonance imaging (MRI). Setting and Design : T0 he case group (n=24) was matched in gender and age range with NC subjects (n=24). Subjects were divided into three groups according to age: 2-5.9 years, 6-8.9 years and 9-13 years.
M0 anual measurements were used to obtain HCVs on oblique coronary MRI images obtained by three-dimensional magnetization-prepared rapid gradient-echo (3D-MPRAGE) sequence. Statistical Analyses : T0 he HCV was calculated and normalized. Paired t-tests were used to compare the right and left HCVs within each study group. Analysis of covariance (ANCOVA) was used to consider the impact of age and gender on HCVs.
T0 wenty-two patients were diagnosed with definite/probable TLE, and two were non-syndromic focal epilepsy which was distributed in the 2-5.9 years group. The range of left to right mean HCVs of the case and NC group aged 2-13 years was 2014.14 ± 54.32 mm 3 to 2165.31 ± 80.99 mm 3 and 2015.46 ± 26.97 mm 3 to 2100.93 ± 57.33 mm 3 respectively. There were age-related differences in left and right HCV, but no effect of gender. Relative to NC subjects, cases group aged 2-5.9 years had significantly different HCVs, while no significant difference was found in the other two groups. There was significant difference in the right to left HCVs in the case subjects aged 2-5.9 years, but not in the other age groups.
T0 he heterogeneity in the 2-5.9 years age cohort may relate to the increased HCVs. The HCV data from NC subjects may be used as a reference to assess hippocampal abnormalities in clinical practice.
目前很少有研究比较颞叶癫痫（TLE）儿童的海马体积（HCV）。目的：比较 TLE 患儿与正常对照组（NC）的 HCV，并分析磁共振成像（MRI）在儿科患者急性期 HCV 的变化。设置和设计：病例组（n=24）在性别和年龄范围上与 NC 组（n=24）相匹配。根据年龄将受试者分为三组：2-5.9 岁、6-8.9 岁和 9-13 岁。材料和方法：使用手动测量法在三维磁化准备快速梯度回波（3D-MPRAGE）序列获得的斜冠状 MRI 图像上获得 HCV。统计学分析：计算并归一化 HCV。采用配对 t 检验比较各组内左右 HCV。采用协方差分析（ANCOVA）考虑年龄和性别对 HCV 的影响。结果：22 例患者诊断为明确/可能 TLE，2 例为非综合征性局灶性癫痫，分布在 2-5.9 岁组。2-13 岁病例组和 NC 组的左、右 HCV 均值范围分别为 2014.14±54.32mm3 至 2165.31±80.99mm3 和 2015.46±26.97mm3 至 2100.93±57.33mm3。左、右 HCV 存在年龄相关性差异，但不受性别影响。与 NC 组相比，2-5.9 岁年龄组的病例组 HCV 存在显著差异，而其他两组无显著差异。2-5.9 岁年龄组病例组左右 HCV 存在显著差异，但其他年龄组无显著差异。结论：2-5.9 岁年龄组的异质性可能与 HCV 增加有关。NC 组的 HCV 数据可用于临床实践中评估海马异常。
