Marijic J, Stowe D F, Turner L A, Kampine J P, Bosnjak Z J
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
Anesthesiology. 1990 Nov;73(5):976-83. doi: 10.1097/00000542-199011000-00027.
The authors investigated the effects of halothane (HAL) and isoflurane (ISO) on cardiac depression produced by global hypoxia and the recovery of function following reoxygenation is isolated guinea pig hearts perfused with Krebs' solution at constant pressure. Isovolumetric left ventricular systolic (LVSP) and end-diastolic pressures (LVEDP) were measured by placing a saline filled, latex balloon into the left ventricle. Bipolar electrodes were placed in the right atrium and right ventricle for measurements of heart rate (HR), atrioventricular conduction time (AVCT), and determination of the incidence and severity of dysrhythmias occurring during hypoxia and reoxygenation. Hearts were divided into three groups: control (n = 20), halothane (n = 12), and isoflurane (n = 13). All hearts were exposed in sequence to oxygenated perfusate (PO2, 530 mmHg), moderately hypoxic perfusate (PO2, 91 mmHg) for 30 min, and then to oxygenated perfusate for 40 min. Halothane (1%, 0.4 mM) or isoflurane (1.5%, 0.5 mM) were administered 10 min before hypoxia, during hypoxia, and during the first 10 min of reoxygenation. Exposure to halothane and isoflurane before hypoxia produced a 14 and 11% decrease in heart rate, a 32 and 23% increase in AVCT, and a 47 and 28% decrease in LVSP (all P less than or equal to 0.001) for halothane and isoflurane, respectively, and no significant change in LVEDP. During hypoxia, HR decreased and AVCT increased similarly in both groups. Left ventricular systolic pressure (LVSP) decreased sharply with a narrowing of the prehypoxic differences among the groups. In the control and isoflurane groups, LVEDP increased during hypoxia but remained unchanged in the halothane group.(ABSTRACT TRUNCATED AT 250 WORDS)
作者研究了氟烷（HAL）和异氟烷（ISO）对整体缺氧所致心脏抑制的影响，以及在恒压下用 Krebs 溶液灌注的离体豚鼠心脏复氧后功能的恢复情况。通过将充满盐水的乳胶气球放入左心室来测量等容左心室收缩压（LVSP）和舒张末期压力（LVEDP）。将双极电极置于右心房和右心室，以测量心率（HR）、房室传导时间（AVCT），并确定缺氧和复氧期间发生心律失常的发生率和严重程度。心脏分为三组：对照组（n = 20）、氟烷组（n = 12）和异氟烷组（n = 13）。所有心脏依次暴露于含氧灌注液（PO2，530 mmHg）、中度缺氧灌注液（PO2，91 mmHg）30 分钟，然后再暴露于含氧灌注液 40 分钟。在缺氧前 10 分钟、缺氧期间和复氧的前 10 分钟给予氟烷（1%，0.4 mM）或异氟烷（1.5%，0.5 mM）。缺氧前暴露于氟烷和异氟烷分别使心率降低 14%和 11%，AVCT 增加 32%和 23%，LVSP 降低 47%和 28%（所有 P 均小于或等于 0.001），LVEDP 无显著变化。在缺氧期间，两组的 HR 均下降，AVCT 均增加。左心室收缩压（LVSP）急剧下降，组间缺氧前差异缩小。在对照组和异氟烷组中，LVEDP 在缺氧期间增加，但在氟烷组中保持不变。（摘要截短于 250 字）
