比较各种局部抗青光眼药物对睑板腺的长期影响。

Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands.

机构信息

Itoh Clinic, Saitama, Japan.

出版信息

Cornea. 2012 Nov;31(11):1229-34. doi: 10.1097/ICO.0b013e31823f8e7d.

DOI:10.1097/ICO.0b013e31823f8e7d

PMID:22406943

Abstract

PURPOSE

To examine the effects of long-term antiglaucoma eye drop treatment on meibomian glands.

METHODS

The subjects were 71 eyes of 71 glaucoma patients (group 1) receiving one type of antiglaucoma eye drops, 61 eyes of 61 glaucoma patients (group 2) receiving two types of antiglaucoma eye drops, and 30 eyes of 30 glaucoma patients (group 3) receiving three types of antiglaucoma eye drops. Controls comprised 75 eyes of 75 healthy volunteers. Subjective symptoms were evaluated by questionnaire, and lid margin and superficial punctate keratopathy were evaluated by slit lamp examination. Meibomian glands of upper and lower eyelids were observed and scored using noncontact meibography (meiboscore). Tear film break-up time (BUT) was measured and meibum was graded.

RESULTS

Lid margin abnormality, superficial punctate keratopathy, meiboscore, and meibum scores were significantly higher in glaucoma patients than in controls (P < 0.001). BUT and Schirmer scores were significantly lower in glaucoma patients than in controls (P < 0.001). Subgroup analysis of the parameters in group 1 revealed no significant difference between patients receiving prostaglandin and those receiving β-blockers, or among groups 1, 2, and 3. Multivariate regression analysis demonstrated that meiboscore significantly correlated with lid margin abnormality score (P = 0.007) and BUT (P = 0.045) in group 1; with BUT (P = 0.004), symptom score (P = 0.003), and age (P = 0.026) in group 2; and with lid margin abnormality score (P = 0.001) in group 3.

CONCLUSIONS

Long-term use of antiglaucoma eye drops was associated with alterations in meibomian gland morphology and function.

摘要

目的

研究长期抗青光眼滴眼治疗对睑板腺的影响。

方法

研究对象为 71 例（1 组）、71 只眼接受一种抗青光眼滴眼剂，61 例（2 组）、61 只眼接受两种抗青光眼滴眼剂，30 例（3 组）、30 只眼接受三种抗青光眼滴眼剂的青光眼患者，对照组为 75 例（75 只眼）健康志愿者。通过问卷调查评估主观症状，通过裂隙灯检查评估睑缘和浅层点状角膜病变。采用非接触式睑板腺成像（睑板腺评分）观察并评估上下眼睑的睑板腺，测量泪膜破裂时间（BUT）并分级睑脂。

结果

青光眼患者的睑缘异常、浅层点状角膜病变、睑板腺评分和睑脂评分明显高于对照组（P<0.001）。青光眼患者的 BUT 和 Schirmer 评分明显低于对照组（P<0.001）。1 组患者中各参数的亚组分析显示，接受前列腺素和接受β受体阻滞剂的患者之间，以及 1 组、2 组和 3 组之间均无显著差异。多元回归分析显示，1 组中睑板腺评分与睑缘异常评分（P=0.007）和 BUT（P=0.045）显著相关；2 组中与 BUT（P=0.004）、症状评分（P=0.003）和年龄（P=0.026）显著相关；3 组中与睑缘异常评分（P=0.001）显著相关。