Université de Strasbourg, Institut de Chimie, UMR 7177, Laboratoire de Chimie Organique Synthétique, 1 rue Blaise Pascal, BP 296/R8, 67008 Strasbourg-Cedex, France.
Org Biomol Chem. 2012 Apr 28;10(16):3253-7. doi: 10.1039/c2ob07049a. Epub 2012 Mar 12.
Intramolecular reductive coupling of cycloalkanones tethered to alkynoates in the presence of (η(2)-propene)titanium was successfully performed to provide hydroxy-esters in a diastereoselective manner. Subsequent lactonization afforded angularly fused unsaturated tricyclic lactones which represent relevant substructures of numerous bioactive compounds.
在（η(2)-丙烯）钛的存在下，成功地进行了与炔酸酯键合的环烷酮的分子内还原偶联，以非对映选择性方式提供了羟基酯。随后的内酯化得到了角并合的不饱和三环内酯，它们代表了许多生物活性化合物的相关亚结构。
