Department of Physiology, Faculty of Pharmacy, University of Belgrade, 450 Vojvode Stepe, 11221 Belgrade, Serbia.
Immunol Res. 2012 Apr;52(1-2):7-19. doi: 10.1007/s12026-012-8278-6.
There is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually diergic changes in thymopoietic efficiency, which in rodents occur around puberty and lead to a substantial phenotypic and functional remodeling of the peripheral T-cell compartment. This in turn leads to an alteration in the susceptibility to infection and various immunologically mediated pathologies. Our laboratory has explored interdependence in the programming and development of the hypothalamo-pituitary-gonadal axis and thymus using experimental model of neonatal androgenization. We have outlined critical points in the complex process of T-cell development depending on neonatal androgen imprinting and the peripheral outcome of these changes and have pointed to underlying mechanisms. Our research has particularly contributed to an understanding of the putative role of changes in catecholamine-mediated communications in the thymopoietic alterations in adult neonatally androgenized rats.
越来越多的证据表明，新生儿类固醇环境在编程胸腺生成效率的性别二态性变化中起着重要作用，这种变化发生在青春期前后，导致外周 T 细胞区室的实质性表型和功能重塑。这反过来又导致对感染和各种免疫介导的病理的易感性发生改变。我们的实验室使用新生雄激素化的实验模型探索了下丘脑-垂体-性腺轴和胸腺的编程和发育之间的相互依存关系。我们已经概述了依赖于新生雄激素印记的 T 细胞发育的复杂过程中的关键点，以及这些变化的外周后果，并指出了潜在的机制。我们的研究特别有助于理解儿茶酚胺介导的通讯变化在新生雄性大鼠胸腺生成改变中的潜在作用。
