Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
Ocul Immunol Inflamm. 2012 Apr;20(2):100-3. doi: 10.3109/09273948.2011.646383.
To study the prevalence, microbial profile, and risk factors for ocular involvement in patients with candidemia.
The records of all inpatient consultations requested at the Brigham and Women's Hospital from October 2009 to June 2011 to evaluate for ocular involvement in patients with candidemia were retrospectively reviewed.
Forty-nine consults were requested to rule out ocular involvement in patients with candidemia. The mean patient age was 55 years. In decreasing frequency, the organisms isolated were Candida albicans (42%), Candida parapsilosis (23%), Candida glabrata (17%), Candida tropicalis (8%), Candida dublinensis (5%), Candida krusei (3%), and Candida lusitaniae (3%). All patients were on antifungal treatment at the time of their initial ophthalmologic examination. One patient had evidence of chorioretinitis, and 3 patients had nonspecific fundus findings. Common risk factors included presence of an intravenous catheter, malignancy, and abdominal surgery.
Ocular involvement is rare among patients with systemic Candida infection.
研究念珠菌血症患者眼部受累的患病率、微生物谱和危险因素。
回顾性分析 2009 年 10 月至 2011 年 6 月在布莱根妇女医院因念珠菌血症而请求评估眼部受累的所有住院患者会诊记录。
为排除念珠菌血症患者的眼部受累，共请求了 49 次会诊。患者的平均年龄为 55 岁。分离出的病原体依次为白念珠菌（42%）、近平滑念珠菌（23%）、光滑念珠菌（17%）、热带念珠菌（8%）、都柏林念珠菌（5%）、克柔念珠菌（3%）和葡萄牙念珠菌（3%）。所有患者在首次眼科检查时均接受了抗真菌治疗。1 例患者有脉络膜视网膜炎证据，3 例患者有非特异性眼底发现。常见的危险因素包括静脉导管、恶性肿瘤和腹部手术。
在系统性念珠菌感染患者中，眼部受累罕见。
