Pujol R
INSERM, U 254, Université de Montpellier II, Hôpital St Charles.
Ann Otolaryngol Chir Cervicofac. 1990;107 Suppl 1:36-47.
Our concept of cochlear physiology has changed so drastically over the last decade that most classical textbooks have become obsolete. This bibliographical inadequacy regarding the functioning of the normal cochlea is particularly disturbing when it comes to addressing patho-physiology problems (hearing loss or tinnitus). What drastic changes have there been, that can justify such need for information updating? These relate primarily to the role of one the two types of sensory cells of the cochlea; i.e., the outer hair cells (or OHC). These cells are endowed with contractile properties and react to tonal impulse by modifying the vibration of the cochlear partition. This "active mechanism" response provokes a localized amplification of the vibration imparting to these classical sensory transducers, or inner hair cells (IHC), their optimal frequency sensitivity and discrimination properties. This new concept alone would suffice to justify our present topic. We chose, however, to insert a general presentation of cochlear physiology, the intent of which is to briefly review the classical data and to analyze in some depth the issues that have drastically changed our knowledge.
在过去十年里,我们对耳蜗生理学的概念发生了如此巨大的变化,以至于大多数经典教科书都已过时。当涉及到解决病理生理学问题(听力损失或耳鸣)时,这种关于正常耳蜗功能的文献不足尤其令人不安。发生了哪些巨大的变化,以至于有必要更新这些信息呢?这些主要与耳蜗两种感觉细胞之一,即外毛细胞(OHC)的作用有关。这些细胞具有收缩特性,并通过改变耳蜗隔板的振动对音调脉冲做出反应。这种“主动机制”反应会引起振动的局部放大,赋予这些经典的感觉换能器,即内毛细胞(IHC)最佳的频率敏感性和辨别特性。仅这一新概念就足以证明我们当前的主题是合理的。然而,我们选择插入一段耳蜗生理学的概述,其目的是简要回顾经典数据,并深入分析那些极大地改变了我们认知的问题。