术前治疗并不能改善直肠腹骶部切除术的治疗效果。

Preoperative treatment does not improve the therapeutic results of abdominosacral amputation of the rectum.

作者信息

Bębenek Marek, Tupikowski Wiesław, Cisarż Karol, Balcerzak Alicja, Wojciechowski Leszek, Stankowska Anna, Tarkowski Radosław

机构信息

1st Department of Surgical Oncology, Regional Comprehensive Cancer Center, pl. Hirszfelda 12, 53-413, Wroclaw, Poland.

出版信息

World J Surg. 2012 Jul;36(7):1686-92. doi: 10.1007/s00268-012-1527-y.

DOI:10.1007/s00268-012-1527-y

PMID:22411086

Abstract

BACKGROUND

This study reviewed the impact of preoperative chemoradiotherapy/short-term radiotherapy on abdominosacral amputations of the rectum (ASAR) for the treatment of low-rectum cancers in terms of postoperative morbidity, local recurrence rates, and survival.

METHODS

A total of 198 patients with stage II and III tumors located within 6 cm of the anorectal junction underwent ASAR between 1998 and 2008 and were selected for further analysis. Patients were compared according to the following groups: those who had surgery only (Group A) and those who had preoperative chemoradiotherapy/short-term radiotherapy (Group B).

RESULTS

There were 44 and 154 patients in Groups A and B, respectively, including 135 males. The median age of the subjects was 63 years (range = 35-88). The median follow-up period was 81 months (range = 23-138). Neither the local recurrence rates (6.8% in Group A vs. 4.6% in Group B, p = 0.544) nor the 5-year relative survival rates (72.4% in Group A vs. 69.3% in Group B, p = 0.127) differed significantly between the groups.

CONCLUSION

Preoperative therapy in low-rectum cancer does not improve the therapeutic results of ASAR.

摘要

背景

本研究回顾了术前放化疗/短期放疗对直肠腹骶切除术（ASAR）治疗低位直肠癌的术后发病率、局部复发率和生存率的影响。

方法

1998年至2008年间，共有198例肿瘤位于距肛门直肠交界处6cm以内的II期和III期患者接受了ASAR，并被选作进一步分析。根据以下分组对患者进行比较：单纯接受手术的患者（A组）和接受术前放化疗/短期放疗的患者（B组）。

结果

A组和B组分别有44例和154例患者，其中男性135例。受试者的中位年龄为63岁（范围=35 - 88岁）。中位随访期为81个月（范围=23 - 138个月）。两组之间的局部复发率（A组为6.8%，B组为4.6%，p = 0.544）和5年相对生存率（A组为72.4%，B组为69.3%，p = 0.127）均无显著差异。