Bespalov V G, Beliaeva O A, Panchenko A V, Stukov A N, Gershanovich M L, Murazov Ia G, Kon'kov S A, Kil'maeva N E, Krylova I M, Mironiuk T A, Latipova D Kh
Vopr Onkol. 2011;57(6):771-4.
Antitumor activity of dioxadet in comparison with cisplatin was studied on the model of ascitic ovarian tumor in 32 female Wistar rats. Ascitic ovarian tumor was transplanted intraperitoneally 0.5 ml per rat dissolved by saline in ratio 1 to 4. Dioxadet (1.5 mg/kg b.w.) and cisplatin (4.0 mg/kg b.w.) were administered intraperitoneally at their single maximal tolerable doses 48 hours after tumor cells transplantation. For drug activity estimation time to ascites detection and survival time values were used. In control group without no treatment the time till ascites occurrence and median life span were 5.4 +/- 0.25 and 7.5 days, correspondingly. In comparison with the control group dioxadet increased the average time of ascites occurrence and median of life span by 30% and 113% (p < 0.05), cisplatin increased these parameters by 28% and 147% (p < 0.05). Hence, antitumor activity of dioxadet is comparable with cisplatin activity for intraperitoneal therapy of the ascitic ovarian tumor.
在32只雌性Wistar大鼠的腹水型卵巢肿瘤模型上，研究了二恶二烯与顺铂相比的抗肿瘤活性。将腹水型卵巢肿瘤以1:4的比例用生理盐水溶解，每只大鼠腹腔注射0.5 ml。在肿瘤细胞移植48小时后，以单次最大耐受剂量腹腔注射二恶二烯（1.5 mg/kg体重）和顺铂（4.0 mg/kg体重）。使用检测腹水的时间和生存时间值来评估药物活性。在未治疗的对照组中，出现腹水的时间和中位寿命分别为5.4±0.25天和7.5天。与对照组相比，二恶二烯使出现腹水的平均时间和中位寿命分别增加了30%和113%（p<0.05），顺铂使这些参数分别增加了28%和147%（p<0.05）。因此，二恶二烯的抗肿瘤活性与顺铂在腹水型卵巢肿瘤腹腔治疗中的活性相当。
