Zakariaei Zakaria, Taslimi Shervin, Tabatabaiefar Mohammad Amin, Arghand Dargahi Mosa
Department of Medical Sciences and Toxicology, School of Medicine, Tehran University of Medical Sciences, Iran.
Acta Med Iran. 2012;50(3):213-5.
Drug induced dystonic reactions are among common presentations of patients in emergency departments, and typically occur with antidopaminergic agents as their extra-pyramidal side effects. Dystonic reactions usually occur within the first few hours or days after commencing a drug or dose increase. Unlike other extra-pyramidal side effects, a patient may experience acute dystonic reactions (ADRs) with the administration of just a single dose. Oromandibular dystonia is a subtype of dystonia which can present with perioral manifestations. In extreme cases, it can lead to temporomandibular dislocation. Haloperidol, as a high potent typical antipsychotic drug, can induce dystonia with blocking D2 dopamine receptors. The present paper reports a case of bilateral dislocation of temporomandibular joint following ingestion of haloperidol in a suicidal attempt in a 17 years old girl.
药物性肌张力障碍反应是急诊科患者的常见表现之一,通常作为抗多巴胺能药物的锥体外系副作用而出现。肌张力障碍反应通常在开始用药或增加剂量后的最初几小时或几天内发生。与其他锥体外系副作用不同,患者仅服用单剂量药物就可能出现急性肌张力障碍反应(ADR)。口下颌肌张力障碍是肌张力障碍的一种亚型,可表现为口周症状。在极端情况下,可导致颞下颌关节脱位。氟哌啶醇作为一种高效的典型抗精神病药物,可通过阻断D2多巴胺受体诱发肌张力障碍。本文报道了一名17岁女孩自杀未遂服用氟哌啶醇后发生双侧颞下颌关节脱位的病例。